Sumo chains: polymeric signals

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August undefined, 2024

WebSUMO chain formation is reversible; SUMO polymers are disassembled by SUMO proteases both in vitro and in vivo. SUMO chains play roles in replication, in the turnover of SUMO … WebSmall ubiquitin-like modifiers (SUMOs) regulate virtually all nuclear processes. The fate of the target protein is determined by the architecture of the attached SUMO protein, which …

SUMO chains: polymeric signals. - Abstract - Europe PMC

Web28 Feb 2010 · Title: SUMO chains: polymeric signals: Author: Vertegaal, A.C.O. Date issued: 2010-02-28: Access: Closed Access: Language: English: Type: Article: Abstract: Ubiquitin … Web10 Jan 2024 · One signaling process initiated by SUMO chains is the SUMO-targeted Ubiquitin ligase (StUbL) pathway. In this evolutionary conserved pathway, poly- (or multi-) … pirjo haapanen

Polymeric Chains of SUMO-2 and SUMO-3 Are Conjugated to …

WebThrough these interactions, SUMO chains exert effects on meiosis and chromatin structure. Recently, additional polySUMO-binding proteins, including Arkadia, FLASH, C5orf25 and … WebMonomeric and polymeric forms of SUMO and ubiquitin are covalently ... SUMO-Ub chains may also function as signals that affect lysosomal . ... Hybrid suMo-ub chain receptors. … pirjo hakala-lahtinen

SUMO Chains Rule on Chromatin Occupancy - PMC - PubMed …

Decoding the SUMO signal Biochemical Society Transactions

Web7 Nov 2008 · In mammalian cells, the RING finger E3 RNF4 bears four closely spaced SIMs in its N-terminal region (Figure 2A).All of them contribute to SUMO binding, and although … Web7 Nov 2008 · SUMO ligases generally enhance free chain formation and often stimulate the assembly of long polymeric conjugates on suitable substrates in vitro, but at least under … atlanta digital marketing strategyWeb21 Mar 2013 · Ronald T. Hay; Decoding the SUMO signal. Biochem Soc Trans 1 April 2013; 41 (2): 463–473. doi: ... Like ubiquitin, SUMO can form polymeric chains, and these chains … pirjo hakonen

"WebThe SUMO monomers display homogeneous fluorescence spots at the single-molecule level, whereas the mixed SUMO chains exhibit nonuniform fluorescence spots with a wide … " - Sumo chains: polymeric signals

Sumo chains: polymeric signals

Web16 Jan 2016 · In this mechanism, a tandem array of SUMO interaction motifs (SIMs) in STUbLs enables them to selectively ubiquitylate target proteins that are modified by … WebInvestigations into the biological role of polymeric chains have been hampered by the absence of a protocol for the purification of proteins linked to SUMO chains. In this paper, …

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Web19 Jan 2010 · SUMO chains play roles in replication, in the turnover of SUMO targets by the proteasome and during mitosis and meiosis. Thus signalling via polymers is an exciting … Web1 Feb 2010 · SUMO chains: polymeric signals. Ubiquitin and ubiquitin-like proteins are conjugated to a wide variety of target proteins that play roles in all biological processes. …

WebPosttranslational modification of proteins by the small ubiquitin-like modifier (SUMO) is a potent regulator of various cellular events. Hundreds of substrates have been identified, … Web27 Jun 2014 · The small ubiquitin-like modifier (SUMO) can form polymeric chains that are important signals in cellular processes such as meiosis, genome maintenance and stress …

Web1 Feb 2024 · The SUMO-targeted ubiquitin ligases (STUbLs) RING-finger protein 4 (RNF4) and RNF111 recognize SUMO polymers in a chain-architecture-dependent manner, leading … WebThe small ubiquitin-like modifier (SUMO) can form polymeric chains that are important signals in cellular processes such as meiosis, genome maintenance and stress response. …

WebPost-translational modification by SUMO is a dynamic and reversible process and several SUMO-specific proteases that remove SUMO from substrates have been identified. We …

WebPost-translational modification by small ubiquitin-like modifier (SUMO) has emerged as a global mechanism for the control and integration of a wide variety of biological processes … atlanta digital marketing agenciesWebHere, we developed a novel approach for analyzing polymeric SUMO2/3 chain signals by transfecting cells with the DNA construct encoding GFP-tagged four tandem SUMO … atlanta diningWeb1 Feb 2010 · This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our privacy … pirjo hamariWeb1 Apr 2024 · Unfortunately, the capture of interactors such as RNF4 and RNF111 using diSUMO-2 pull-down probes proved very difficult (data shown below), mainly because the … pirjo hannele heinävesiWeb6 Feb 2024 · Author summary The Small ubiquitin-related modifier (SUMO) is a 100 amino acid protein that is attached to other proteins and thereby regulates nearly all essential … atlanta digital marketing servicesWebSUMO (small ubiquitin-related modifier) shares the ability of ubiquitin to form chains via internal SUMOylation sites. Interestingly, a SUMO-binding site in Ubc9 is important for … atlanta dining setWebT1 - Decoding the SUMO signal. AU - Hay, Ronald T. PY - 2013/4. ... Like ubiquitin, SUMO can form polymeric chains, and these chains can be recognized by proteins containing … pirjo halonen