WebFeb 28, 2024 · 17 and microRNAs – to complete its viral life cycle. The cellular RNA-binding protein poly(rC)-18 binding protein 1 (PCBP1) had previously been reported to bind the HCV genome 5´ 19 untranslated region (UTR), but its importance in the viral life cycle has remained unclear. 20 Herein, we aimed to clarify the role of PCBP1 in the HCV life cycle. WebMar 3, 2009 · The poly(C)-binding proteins (PCBPs) are characterized by high affinity for, and sequence-specific interaction with polycytosine, poly(C). In mammalian cells, these PCBPs belong to one of two subsets: hnRNP K/J, or the alpha-complex proteins (e.g., PCBP1-4) []. hnRNP K, PCBP1, and PCBP2 have been studied in the greatest detail.The latter two …
Poly(rC)-binding protein 1 represses ferritinophagy-mediated ...
WebSep 1, 2015 · PCBP1 is an intron‐less gene encoding the 356 amino acid poly(rC) binding protein 1, which contains three K‐Homology (KH) domains and two nuclear localization signals. The mutations predominantly (10/12, 83%) affect the KH III domain, either by complete domain loss or amino acid changes. WebMay 1, 2024 · Poly(rC)-binding protein 1 (PCBP1) is a multifunctional RNA-binding protein that plays various roles in gene transcription, RNA regulation, and iron chaperone [8, 9]. … imo 64 bit download
Poly (rC) binding protein 1 represses the translation of STAT3 …
WebDec 8, 2024 · Poly(rC) Binding Protein 1 Represses the Translation of STAT3 through 5' UTR. Li Z, Wang X, Jia RLi Z, et al. Curr Gene Ther, 2024. PMID 35549870; Poly(rC)-Binding … WebAug 21, 2024 · However, splicing factors can also play negative roles in tumorigenesis. In the current review, we focus on splicing factor poly(rC)-binding protein 1 (PCBP1), a novel … WebMay 10, 2024 · Objective To monitor the phosphorylation modifications and cellular localization of poly(rC)-binding protein-1 (PCBP1) during the cell cycle progression of Hela cells. Result Hela cells highly synchronized at five different phases from interphase to mitosis were obtained. Using mitotic phosphoprotein-specific monoclonal antibody MPM … imo 5th grade