WebMembrane associated guanylate kinase, WW and PDZ domain containing 2 (MAGI2) is a gene that encodes a protein that interacts with atrophin-1. Missense mutations, synonymous mutations, nonsense mutations, and frameshift deletions are observed in cancers such as skin cancer, stomach cancer, and colon cancer. WebPlays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation ( By similarity ). Involved in the regulation of synaptic function in excitatory hippocampal synapses.
MAGI2 Gene - GeneCards MAGI2 Protein MAGI2 …
WebProtein structure for human protein MAGI2 (ACVRIP1, AIP1, ARIP1, KIAA0705, MAGI-2) We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. ... GO:0010976 [positive regulation of neuron projection development] GO:0014069 [postsynaptic density] GO:0016020 [membrane] GO ... WebMay 23, 2012 · MAGI2, a relatively large gene (∼1.5 Mbps) that maps to chromosome 7q21, is involved in recruitment of neurotransmitter receptors such as AMPA- and NMDA-type glutamate receptors. A genetic association study designed to evaluate the association between MAGI2 and cognitive performance or schizophrenia has not been conducted. call from bt openreach about internet
MAGI-2 is critical for the formation and maintenance of the ... - PubMed
WebMar 1, 2012 · MAGI-2 (also referred to as Synaptic scaffolding molecule; S-SCAM) was localized to the postsynaptic density (PSD) area of neuronal membranes ( Hirao et al., 1998 ). Supporting its putative role in neuronal function, MAGI-2 was reported to bind to the known N -methyl- d -aspartate glutamate receptor (NMDAR). WebMay 5, 2012 · Neuron transfection and immunocytochemistry. Dissociated hippocampal neuron culture was prepared from E18 embryos of either sex as described previously (Lee et al., ... et al. Infantile spasms is associated with deletion of the MAGI2 gene on chromosome 7q11.23-q21.11. Am J Hum Genet. 2008; 83:106–111. [PMC free article] … WebApr 6, 2024 · There are three main types of neurons: Motor neurons make the connection between the brain and muscles throughout the body. These neurons transmit electrical impulses containing information to skeletal muscles and smooth muscles. Motor neurons control all of our body movement. Sensory neurons are neurons that let us feel sensation. cobblers hinckley