WebMechanistically, HIF-1α directly bound to the GPX4 gene promoter region and promoted GPX4 transcription. AKT inhibitor MK-2206 and HIF-1α inhibitor PX-478 could signicantly reverse the effect. Besides, under normoxia, PX-478 could induce a higher lipid peroxidation level by decreasing GPX4 expression in U87 and U251 cells but cannot induced ... Web18 de fev. de 2024 · The activity of HIF is mainly regulated by oxygen-dependent proteolysis of the α-subunits . HO-1 is one of the HIF target genes . Therefore, HIF-1α also regulates …
Trabectedin induces ferroptosis via regulation of HIF-1α/IRP1
Web29 de abr. de 2024 · HIF-2α mediated iron toxicity and accumulation of lipid ROS, which synergized with ferroptotic activators to enhance CRC cell death. HIF-2α also increased … WebThe results showed that HIF-1 α and xCT declined, which induced the GPX4 decreased(Fig.3). Conclusion Our study provides significant evidence to confirm the occurrence of ferroptosis in hematological malignant cells treated with pim inhibitors, and demonstrates that inhibition of ferroptosis was through HIF-1 α /GPX4 pathway. foam extinguisher is used for
Ferroptotic cell death triggered by conjugated linolenic …
Web4 de mar. de 2024 · In conclusion, our findings indicated that ferroptosis plays a crucial role in the development of ATB-DILI. Furthermore, anti-TB drug-induced hepatocyte ferroptosis was shown to be regulated by HIF-1α/SLC7A11/GPx4 signaling. These findings shed new light on the mechanisms underlying ATB-DILI and suggest novel therapeutic strategies … Web27 de out. de 2024 · HIF-1, existing in the form of functional heterodimer which consisting of α and β (aryl hydrocarbon receptor nuclear translocator, ARNT) isoforms, is a primary … Web9 de ago. de 2024 · The GPX4-dependent and ferroptosis-susceptible state in ccRCC is associated with PUFA-lipid abundance The HIF-2α–HILPDA axis promotes the selective … greenwich to stratford