WebMar 29, 2024 · Di-(2-ethylhexyl) phthalate (DEHP) and mono-2-ethylhexyl phthalate (MEHP) can induce hepatic lipid metabolism disorders, while the molecular mechanism still remain unknown. We aim to explore the underlying mechanism of Notch signaling pathway on hepatic lipid accumulation induced by DEHP/MEHP. A total of 40 male wistar rats … WebJan 31, 1987 · Basis: Orally administered DEHP produced significant dose-related increases in liver tumor responses in rats and mice of both sexes. This may be a synopsis of the full weight-of-evidence narrative. …
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WebTechnical Factsheet on: DI (2-ETHYLHEXYL) PHTHALATE (DEHP) List of Contaminants As part of the Drinking Water and Health pages, this fact sheet is part of a larger publication: National Primary Drinking Water Regulations . Drinking Water Standards MCLG: zero MCL: 0.006 mg/L HAL(child): none . Health Effects Summary WebExposure to DEHP also occurs in hospital environments, where DEHP leaches directly into liquids that passed through PVC/DEHP tubing and equipment. The latter exposure is at considerably higher levels compared to food and bottled water, specifically putting patients with chronic illnesses at risk.
WebFeb 22, 2024 · Di-2-ethylhexyl phthalate (DEHP) is extensively used as a plasticizer in many products, especially medical devices, furniture materials, cosmetics, and personal … WebJan 31, 1987 · Basis: Orally administered DEHP produced significant dose-related increases in liver tumor responses in rats and mice of both sexes. This may be a synopsis of the full weight-of-evidence narrative. …
WebDec 2, 2015 · Di-(2-ethylhexyl)-phthalate (DEHP), an ubiquitous environmental contaminant, has been shown to cause adverse effects on glucose homeostasis and insulin sensitivity in epidemiological studies, but the underlying mechanisms are still unknown. We therefore tested the hypothesis that chronic DEHP exposure causes impaired insulin … Bis(2-ethylhexyl) phthalate (di-2-ethylhexyl phthalate, diethylhexyl phthalate, diisooctyl phthalate, DEHP; incorrectly — dioctyl phthalate, DIOP) is an organic compound with the formula C6H4(CO2C8H17)2. DEHP is the most common member of the class of phthalates, which are used as plasticizers. It is the … See more Di(2-ethylhexyl) phthalate is produced commercially by the reaction of excess 2-ethylhexanol with phthalic anhydride in the presence of an acid catalyst such as sulfuric acid or para-toluenesulfonic acid. It was first produced … See more DEHP is a component of many household items, including tablecloths, floor tiles, shower curtains, garden hoses, rainwear, dolls, toys, shoes, medical tubing, furniture upholstery, and swimming pool liners. DEHP is an indoor air pollutant in homes and schools. … See more Taiwan In October 2009, Consumers' Foundation, Taiwan (CFCT) published test results that found 5 out of the … See more • FDA Public Health Notification: PVC devices containing the plasticizer DEHP (archived page) • ATSDR ToxFAQs • CDC - NIOSH Pocket Guide to Chemical Hazards See more Due to its suitable properties and the low cost, DEHP is widely used as a plasticizer in manufacturing of articles made of PVC. Plastics may contain 1% to 40% of DEHP. It is also used as a See more Toxicity The acute toxicity of DEHP is low in animal models: 30 g/kg in rats (oral) and 24 g/kg in rabbits (dermal). … See more • Maradonna, Francesca; Evangelisti, Matteo; Gioacchini, Giorgia; et al. (2013). "Assay of vtg, ERs and PPARs as endpoint for the rapid in vitro screening of the harmful effect of Di-(2-ethylhexyl)-phthalate (DEHP) and phthalic acid (PA) in zebrafish primary … See more
WebApr 7, 2004 · Human exposure to di(2-ethylhexyl) phthalate (DEHP) occurs throughout life. Of particular concern is the exposure of fetuses, preterm infants, and babies because the developing human reproductive system may be affected when the metabolic pathways of detoxification are immature. DEHP has been shown to damage the male and female …
WebJan 26, 2024 · Di (2-ethylhexyl) phthalate ( DEHP) is the type used the most in medical devices such as: intravenous (IV) tubing. umbilical artery catheters. blood bags and … opwdd albany officeWebDi(2-ethylhexyl) phthalate (DEHP) by Tamie Nakajima PhD, Nancy B. Hopf PhD, and Paul A. Schulte PhD Citation for most recent IARC review IARC Monographs Vol 77, 2000. The use of di(2-ethylhexyl) phthalate (DEHP) has been modified since the last Monograph. An estimated 90% of DEHP is used as a plasticizer for PVC (Toxics Use Reduction Institute portsmouth history departmentWebSep 1, 2024 · Di-(2-ethylhexyl) phthalate (DEHP), a ubiquitous industrial pollutant, is a known endocrine disrupter implicated in metabolic diseases. Prenatal DEHP exposure promotes epigenetic multi- and transgenerational inheritance of adult onset disease in subsequent generations (F1-F3). However, the epigenetic toxicity is less understood in … opwdd and medicaidWebDEHP has been detected in placenta, amniotic fluid, fetal liver, and other fetal tissues in exposed rats. Mammary milk contains and transfers DEHP and mono--ethylhexyl)phthalate(2 (MEHP) to nursing rat pups. Tissue lipases, esterases, and gut microflora hydrolyze DEHP. DEHP metabolites are further metabolized by cytochrome … portsmouth historical society portsmouth riWebDEHP, Di(2-ethylhexyl)phthalate, DOP, bis-(2-Ethylhexyl)phthalate, Octyl phthalate Colorless, oily liquid with a slight odor. Skip directly to site content Skip directly to page options Skip directly to A-Z link. Centers for Disease Control and … opwdd article 16 crosswalkWebOEHHA 2009. Air Toxics Hot Spots Program Technical Support Document for Cancer Potencies. Appendix B. Chemical-specific summaries of the information used to derive unit risk and cancer potency values. Updated 2011. OEHHA 1997. Public Health Goal for Di (2-ethylhexyl)phthalate (DEHP) in Drinking Water. portsmouth hmo licenceWebDi(2-ethylhexyl)phthalate (DEHP) is a man-made chemical. It is a colorless liquid with a slight odor. DEHP is added to plastics to make them flexible. It can be present in many … portsmouth historic house associates