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Citrate transporter family protein

WebLiver cells import citrate through the sodium-dependent citrate transporter NaCT (encoded by SLC13A5) and, as a consequence, this protein is a potential target for anti-obesity drugs. Here, to understand the structural basis of its inhibition mechanism, we determined cryo-electron microscopy structures of human NaCT in complexes with citrate or ... WebApr 13, 2024 · The inhibited key enzymes in the citrate cycle highlighted inactive energy ... WU75_10380, WU75_10390, and WU75_10385), encoding a choline ABC transporter ATP-binding protein, a choline ABC transporter substrate-binding protein ... transporter periplasmic adaptor subunit and a multidrug transporter. The RND family efflux pumps ...

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WebSLC25 is the largest solute transporter family in humans. 53 members have been ... (SLC25A1, or citrate transport protein; TC# 2.A.29.7.2) Graves disease carrier protein … WebMay 14, 2024 · To study the citrate transport mechanism of CT, the citrate transporter gene was expressed in Escherichia coli, and its product was purified. The citrate … how big are lps https://mihperformance.com

Citrate transport and metabolism in mammalian cells: prostate ...

WebThe partially compromised nodule functioning induces two striking phenotypes: anthocyanin accumulation already displayed 4 weeks after inoculation and shoot biomass deficiency, which is detected by long-term phenotyping. LjNPF8.6 achieves nitrate uptake in Xenopus laevis oocytes at both 0.5 and 30 mm external concentrations, and a possible role ... WebNational Center for Biotechnology Information WebThis gene encodes a sodium-driven citrate transport protein named NaCT. Disease-causing mutations abolish the uptake of citrate in neurons of the brain. ... (NaDC) from the SLC13 family. A number of mutations have been identified in the NaCT transporter gene (SLC13A5) in patients with epileptic encephalography. The Pajor Lab explores what … how big are lion teeth

Frontiers Tripartite ATP-Independent Periplasmic (TRAP) …

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Citrate transporter family protein

OsFRDL1 Is a Citrate Transporter Required for Efficient …

WebMay 14, 2024 · The citrate transport activity of the protein was studied in CT reconstituted liposomes. Our results showed high efficiency of CT for [ 14 C] citrate/citrate exchange with K m 0.01 mM at 25°C. WebTricarboxylate transport protein, mitochondrial, also known as tricarboxylate carrier protein and citrate transport protein (CTP), is a protein that in humans is encoded by …

Citrate transporter family protein

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WebWe have characterized a nodule-specific citrate transporter of the multidrug and toxic compound extrusion family, MtMATE67 of Medicago truncatula The MtMATE67 gene was induced early during nodule development and expressed primarily in the invasion zone of mature nodules. The MtMATE67 protein was localized to the plasma membrane of … WebSep 29, 2012 · The 2-oxoglutarate carrier (OGC) belongs to the mitochondrial carrier protein family whose members are responsible for the exchange of metabolites, cofactors and nucleotides between the cytoplasm and mitochondrial matrix. Initially, OGC was characterized by determining substrate specificity, kinetic parameters of transport, …

WebAluminum-activated malate transporter 1. Gene. ALMT1. Status. UniProtKB reviewed (Swiss-Prot) ... Al tolerance QTL also found on chromosome 1. Acts in parallel but independently of MATE, an aluminum-activated root citrate transporter. ... Protein family/group databases. TCDB. 2.A.85.2.3 the aromatic acid exporter (arae) family; … WebAug 1, 2024 · The recently determined crystal structure of the bacterial Na +-citrate symporter CitS provides unexpected structural and mechanistic insights. The protein has a fold that has not been seen in other proteins, but the oligomeric state, domain organization and proposed transport mechanism strongly resemble those of the sodium …

WebJul 1, 2007 · The cellular transport of long-chain fatty acids (LCFAs) across the plasma membrane has long been thought to occur via passive diffusion. However, in recent years a substantial body of literature has emerged indicating that LCFA uptake into muscle cells occurs via a protein-mediated process (for review see Bonen et al. 2002; Luiken et al. … WebSLC13A5. Solute carrier family 13 (sodium-dependent citrate transporter), member 5 also known as the Na+/citrate cotransporter or mIndy is a protein that in humans is encoded by the SLC13A5 gene. [5] It is the mammalian homolog of the fly Indy gene .

WebOct 10, 2013 · The SLC13 family in humans and other mammals consists of sodium-coupled transporters for anionic substrates: three transporters for dicarboxylates/citrate and two transporters for sulfate. This review will focus on the di- and tricarboxylate transporters: NaDC1 (SLC13A2), NaDC3 (SLC13A3), and NaCT (SLC13A5). The substrates of these …

WebNov 14, 2008 · Recently, three studies have reported that some MATE proteins are involved in the transport of citrate, which is required for iron (Fe) translocation or … how big are lions clawsWebMar 21, 2024 · This gene encodes a protein belonging to the solute carrier family 13 group of proteins. This family member is a sodium-dependent citrate cotransporter that may … how big are lightning boltsWebJan 20, 2024 · Moreover, mutations of a member of the citrate transporter family in fruit fly, INDY, promote longevity, ... Inhibitors of the mitochondrial citrate transport protein: validation of the role of ... how big are loveseatsWebDec 15, 2024 · Iacobazzi et al. (1997) determined that the open reading frame of the human citrate transporter gene encodes a mature protein of 298 amino acids and a … how big are lymph nodes in armpitWebFeb 12, 2024 · As the prototype for the TTT family, the TctC citrate transporter was first described by Sweet et al. (1979) in the pathogen Salmonella typhimurium, one of the most important causative agents of food-borne gastrointestinal infections and a growing problem due to the recent emergence of multidrug resistant strains (Hur et al., 2012). how big are lurcher dogsWebJan 22, 2024 · The mitochondrial citrate/isocitrate carrier, CIC, has been shown to play an important role in a growing list of human diseases. CIC belongs to a large family of nuclear-encoded mitochondrial transporters that serve the fundamental function of allowing the transit of ions and metabolites through the impermeable mitochondrial membrane. how big are lurchersWebAbstract. Citrate, an organic trivalent anion, is a major substrate for generation of energy in most cells. It is produced in mitochondria and used either in the Krebs' cycle or released … how big are lionfish