Cisplatin resistance and pd-l1
WebPD-L1 in cancer cells, PD-L1 in TILs, and PD-1 in TILs took up 59.1%, 47.0%, and 60.6%, respectively. The data indicated that both dMMR and PD-L1 overexpression resulted … WebCisplatin is one of the most effective broad-spectrum anticancer drugs. Its effectiveness seems to be due to the unique properties of cisplatin, which enters cells via multiple …
Cisplatin resistance and pd-l1
Did you know?
WebThe interaction between programmed cell death-1 (PD-1) and PD-1 ligand 1 (PD-L1) inhibits T-cell activation and proliferation. 4, 5 Several previous studies have reported that PD-L1 overexpression is a predictor of a poor clinical outcome in patients with NSCLC. 6 – 8 On the other hand, PD-L1 overexpression has been shown to be correlated with an … Web14 hours ago · The results indicate that in contrast to erlotinib and cisplatin, osimertinib treatment increased a subset of the HER2 and PD-L1 positive EV population. However, the average expression of the two proteins on individual EVs was found to …
WebMay 1, 2024 · Since PD-L1 expression protects tumor cells from pro-apoptotic drugs, we hypothesized that the PD-1/PD-L1 axis might contribute to the acquisition of resistance … WebOct 21, 2024 · Knockdown of KIFC1 by siRNA increased the sensitivity to cisplatin in BC cells. Kaplan-Meier analysis indicated that prognosis was poor among KIFC1 -positive BC patients treated with cisplatin-based chemotherapy. Immunohistochemistry showed that KIFC1 -positive cases were associated with PD-L1-positive cases.
WebCisplatin is one of the most effective broad-spectrum anticancer drugs. Its effectiveness seems to be due to the unique properties of cisplatin, which enters cells via multiple … WebNov 23, 2024 · It was reported that the combined administration of anti-PD-L1 antibodies and DDP significantly reduced tumor growth compared with single-agent treatments and controls . These findings indicated a key role of PD-L1 in regulating DDP resistance of cancer cells. The survival and proliferation of cancer cells require the expression of cyclin …
WebAug 6, 2024 · PD-L1 binding to PD-1 could negatively regulate the signals of T cell receptor (TCR), reducing TCR-mediated proliferation and production of cytokine. PD-L1 is a key protein that regulates the aggregation and clearance of …
WebPD-L1 increases resistance to radiation or cisplatin by stabilizing NBS1, BRCA1, and other proteins that facilitate the repair of DNA damage ( 5 ). PD-L1 also diminishes IFN-β cytotoxicity by inhibiting an IFN-β–induced STAT3/caspase-7–dependent pathway ( 6 ). inazuma eleven game for android downloadWebApr 11, 2024 · BackgroundProgrammed cell death-ligand 1 (PD-L1) inhibitors plus chemotherapy have made substantial progress in extensive-stage small-cell lung cancer (ES-SCLC), but the survival benefit is still limited. This study aimed to evaluate the preliminary efficacy and safety of camrelizumab plus platinum-irinotecan (IP/IC) followed … inchiostri offsetWebApr 10, 2024 · Several therapeutically relevant markers were identified in EVs collected after cisplatin treatment, including PD-L1 and other proteins regulating PD-L1 export. … inchiology studiosWebNevertheless, the role of PD-L1 in chemoresistance development is not fully understood. In the current study, we aim to clarify the interaction of miR-519d-3p and PD-L1 in the development of cisplatin resistance. Immunohistochemistry, quantitative reverse-transcription polymerase reaction, and Western blot were used to evaluate PD-L1 … inazuma eleven go fanfiction evil tenmaWebSep 9, 2016 · Here we report that cell-intrinsic expression of PD1 and PD-L1, two immune checkpoints, is required for sustained expansion of SCLC cells under cisplatin … inchins san ramonWebSep 9, 2016 · Here we report that cell-intrinsic expression of PD1 and PD-L1, two immune checkpoints, is required for sustained expansion of SCLC cells under cisplatin selection. Indeed, PD1 and PD-L1 were expressed at a higher level in lung cancer cell lines, tumor tissues, and importantly, in SCLC cells resistant to cisplatin (H69R, H82R), when … inazuma eleven game thepiratebayhttp://mars.gmu.edu/handle/1920/13265?show=full inchiostro brother